You'll be waiting a bit if you've got a large disavow...During Google Webmaster hours t'was said

"So if you submit a large disavow file or a disavow file that includes a lot of domain entries or just generally includes a lot of different URLs, then that is something that’s going to take quite a bit of time to kind of recrawl all of those URLs naturally and reprocess all of that information.

So I wouldn’t be surprised if you are looking at a time frame of maybe 3 to 6 to 9 months even for disavow files to be completely taken into account."

This is not suprising...I wonder how much this contributes to the large number of iterations for a manual action that I see a lot of...

Here be the full story:

http://www.thesempost.com/large-disavow-file-google-can-take-3-9-months-process-completely/